Publications

Yoo, H., Boo, K.-J., Nguyen, L. P., Hwang, J.-I., Lee, C. S., Yang, S. H., Jeon, S. J.*, Kim, Hong-Rae*, Kim, H*. Exploring Neurokinin-1 Receptor Antagonism for Depression with Structurally Differentiated Inhibitors. Submitted.

Lee, H., Hurh, S., Kang, S., Yoon, J., Hwang, J.-I.*, Logan, D. T.*, Kim, Hong-Rae*. Identification of Chemical Scaffolds for Targeting Ubiquitin-Specific Protease 11 (USP11) through HIgh-throughput Virtual Screening. Submitted.

Davis, G. J., Omole, A. O., Jung, Y., Rut, W., Holewinski, R., Suazo, K. F., Kim, Hong-Rae, Yang, M., Andresson, T., Drag, M., Yoo, E. Chemical tools to define and manipulate interferon-inducible Ubl protease USP18. Nat. Comm. 2025, 16, 957. (link)

Chung, Y.-H. Park, S., Lee, M., Lee, J., Ji, Y., Song, Y. J., Woo, T.-G., Shin, E., Baek, S., Hwang, Y. J., Kim, Y., Kim, M., Han, J., Kim, Hong-Rae, Choi, J., Kim, B.-H., Park, B.-J. Therapeutic effect of novel drug candidate, PRG-N-01, on NF2 syndrome-related tumor. Neuro-Oncol. 2024, accepted. (link)

Sung, K., Oh, S., Kim, Hong-Rae, Hyeon, S., Ahn J.-H., Kim, S., Aswar, V. R., Tripathi, S. K., Yu, J., Jeong, L. S. Development of 4′-Oxo-MLN4924 as potential neddylation inhibitors: Design, synthesis, anti-HCMV evaluation, and molecular docking. Results Chem. 2024, 11, 101765. (link)

Kim, M., Kim, C., Zheng, H., Kim, Y., Cho, P. S., Lim, J. Y., Choi, W., Kim, M., Kim, Y., Kim, Hong-Rae, Lee, G. Y., Hwang, S. W. Pharmacologic inhibition of Il6st/gp130 improves dermatological inflammation and pruritus. Biomed. Pharmacother. 2024, 178, 117155. (link)

Kim, Hong-Rae, Byun, D. P., Thakur, K., Ritchie, J., Xie, Y., Holewinski, R., Suazo, K. F., Stevens, M., Liechty, H., Tagirasa, R., Jing, Y., Andresson, T., Johnson, S. M., Yoo, E. Discovery of a Tunable Heterocyclic Electrophile 4-Chloro-pyrazolopyridine That Defines a Unique Subset of Ligandable Cysteines. ACS Chem. Biol. 2024, 19, 1972. (link)

Nguyen, T.-U., Hurh, S., In, S., Nguyen, L. P., Cho, M., Mykhailova, K., Kim, Hong-Rae, Ham, B.-J., Choi, Y., Kim, W.-K., Hwang, J.-I. SP-8356 inhibits acute lung injury by suppressing inflammatory cytokine production and immune cell infiltration. Int. Immunopharmacol. 2024, 131, 111847. (link)

Nguyen, L. P.,  Cho, M., Nguyen, T. U., Park, H.-K., Nguyen, H. T., Mykhailova, K., Hurh, S., Kim, Hong-Rae, Seong, J. Y., Lee, C. S., Ham, B.-J., Hwang, J.-I. Neurokinin-2 receptor negatively modulates substance P responses by forming complex with Neurokinin-1 receptor. Cell Biosci. 2023, 13, 212.  (link)

Pham, L., Jiang, R., Liu, Z., Nguyen, M., Nguyen, Y., Gong, Y., Bi, Y., Kim, Kim, Hong-Rae, Y.-R., Kim, G. Synthesis of 9-Cinnamyl-9H-purine Derivatives as Novel TLR4/MyD88/NF-κB Pathway Inhibitors for Anti-inflammatory Effects. ACS Med. Chem. Lett. 2023, 14, 1839. (link)

Nguyen, L. P., Khan, R., Kang, S., Lee, H., Hwang, J.-I.*, Kim, Hong-Rae*. Discovery of Chemical Scaffolds as Lysophosphatidic Acid Receptor 1 Antagonists: Virtual Screening, in vitro Validation and Molecular Dynamics Analysis. ACS Omega, 2023, 8, 40375. (link)

Park, H.-K., Nguyen, L. P., Nguyen, T. U., Cho, M., Nguyen, H. T., Hurh, S., Kim, Hong-Rae, Seong, J. Y., Lee, C. S., Ham, B.-J., Hwang, J.-I. The N-terminus of CXCR4 splice variants determines expression and functional properties. PLoS One, 2023, 18, e0283015. (link)

Byun, D. P., Ritchie, J., Jung, Y., Holewinski, R., Kim, Hong-Rae, Tagirasa, R., Ivanic, J., Weekley, C. M., Parker, M. W., Andresson, T., Yoo, E. Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J. Am. Chem. Soc., 2023, 145, 11097. (link)

Hyun, Y. E., An, S., Kim, M., Park, I. G., Yoon, S., Javaid, H. M. A., Vu, T. N. L., Kim, G., Choi, H., Lee, H. W., Noh, M., Huh, J. Y., Choi, S., Kim, Hong-Rae, Jeong, L. S. Structure-Activity Relationships of Truncated 1'-Homologated Carbaadenosine Derivatives as New PPARγ /δ Ligands: A study on Sugar Puckering Affecting Binding to PPARs. J. Med. Chem., 2023, 66, 4961. (link)

Hyun, Y. E., Dnyandev, D. B., Kim, M., Yang, A., Kim, G., Kim, Hong-Rae*, Jeong, L. S*. Synthesis of Enantiomerically Pure Pyrimidine Ribonucleosides Locked in the South Conformation. Org. Lett., 2022, 24, 9281. (link)

Hyun, Y. E., Kim, Hong-Rae, Jeong, L. S. Stereoselective Synthesis of (S)- and (N)-Cyclopropyl-fused Carbocyclic Nucleosides Using Stereoselective Cyclopropanation. J. Org. Chem., 2021, 86, 9828. (link)

Kim, Hong-Rae, Tagirasa, R., Yoo, E. Covalent Small Molecule Immunomodulators Targeting the Protease Active Site. J. Med. Chem., 2021, 64, 5291. (link)

Heo, M. J., Kang, S. H., Kim, Y. S., Lee, J. M., Yu, J., Kim, Hong-Rae, Lim, H., Kim, K. M., Jung, J., Jeong, L. S., Moon, A., Kim, S. G. UBC12-mediated SREBP-1 neddylation worsens metastatic tumor prognosis. Int. J. Cancer 2020, 147, 2550. (link)

Shin, Y. S., Jarhad, D., Jang, M. H., Kovacikova, K., Kim, G., Yoon, J.-S., Kim, Hong-Rae, Hyun, Y. E., Tipnis, A. S., Chang, T.-S., van Hemert, M. J., Jeong, L. S. Identification of 6'-β-fluoro-homoaristeromycin as a potent inhibitor of chikungunya virus replication. Eur. J. Med. Chem., 2020, 187, 111956. (link)

Kim, Hong-Rae, Jarhad, D., Sahu, P., Sung, K., An, D., Hyun, Y. E., Yu, J., Jeong, L. S. Asymmetric Synthesis of Fluoro-MLN4924 as a Selective NEDD8-Activating Enzyme (NAE) Inhibitor. Asian J. Org. Chem., 2019, 8, 1641. (link)

Yoon, J.-S., Kim, G., Jarhad, D., Kim, Hong-Rae, Shin, Y.-S., Qu, S., Sahu, P.K., Kim, H., Lee, H.W., Wang, S.B., Kong, Y.J., Chang, T.-S., Ogando, N., Kovacikova, K., Snijder, E., Posthuma, C., van Hermert, M., Jeong, L.S. Design, Synthesis and Anti-RNA Virus Activity of 6'-Fluorinated-aristeromycin Analogues. J. Med. Chem., 2019, 62, 6346. (link)

Kim, Hong-Rae, Hyun, Y. E., Jarhad, D., Yu, J., Jeong, L. S. An Alternative and Efficient Synthesis of MLN4924, a Selective NEDD8 Inhibitor. Org. Chem. Front., 2019, 6, 2480. (link)

Yu, J., Kim, G., Jarhad, D., Kim, Hong-Rae, Jeong, L. S. Synthesis and Anti-HIV Activity of L-2',3'-dideoxy-4'-selenonucleosides (L-4'-Se-ddNs). Arch. Pharm. Res., 2019, 42, 780. (link)

Jarhad, D., Jang, M. H., Shin, Y. S., Kim, G., Kim, Hong-Rae, Hyun, Y. E., Yoon, J.-S., Jeong, L. S. An Efficient Synthesis of Fluoro-neplanocin A Analogs using Electrophilic Fluorination and Palladium-catalyzed Dehydrosilylation. Org. Chem. Front., 2019, 6, 959. (link)

Jarhad, D., Mashelkar, K., Kim, Hong-Rae, Noh, M., Jeong, L.S. Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1A (DYRK1A) Kinase Inhibitors as Potential Therapeutics. J. Med. Chem., 2018, 61, 9791. (link)

Yoon, J.-S., Jarhad, D., Kim, G., Nayak, A., Zhao, L.X., Yu, J., Kim, Hong-Rae, Lee, J.Y., Mulamoottil, V.A., Chandra, G., Byun, W.S., Lee, S.K., Kim, Y.-C., Jeong, L.S. Design, Synthesis and Anticancer Activity of Fluorocyclopentenyl-purines and -pyrimidines. Eur. J. Med. Chem., 2018, 155, 406. (link)

Hyun, Y.E., Kim, Hong-Rae, Choi, Y., Jeong, L.S. Stereoselective Synthesis of Anti-Hepatitis B Drug, Entecavir, through Regio- and Stereoselective Epoxide Cleavage. Asian J. Org. Chem., 2017, 6, 1213. (link)

Naik, S.D., Chandra, G., Sahu, P.K., Kim, Hong-Rae, Qu, S., Yoon, J.-S., Jeong, L.S. Stereo- and Regio-selective Synthesis of 3'-C-substituted-(N)-methanocarba Adenosines as Potential Anticancer Agents. Org. Chem. Front., 2016, 3, 1472. (link)